, and the results have been overwhelmingly positive. In this article, we will discuss the science behind nitric oxide supplementation for health and fitness and explore its benefits.
What is Nitric Oxide?
Nitric oxide (NO) is a molecule that our body produces naturally. It plays a vital role in various physiological processes such as vasodilation (widening of blood vessels), neurotransmission, immune response, and inflammation regulation. Nitric oxide also contributes to athletic performance by improving blood flow to muscles during exercise.
How Does Nitric Oxide Supplementation Work?
Supplementing with nitric oxide precursors like L-arginine and L-citrulline can improve NO levels in the body. L-arginine is an amino acid that converts into NO when it enters the bloodstream while L-citrulline converts into arginine before being converted into NO.
When we consume these supplements, they enter our bloodstream and increase the production of NO in our body. This leads to vasodilation which improves blood flow throughout the body including muscles during exercise.
The Benefits of Nitric Oxide Supplementation
1) Improved Cardiovascular Health
One of the most significant benefits of nitric oxide supplementation is improved cardiovascular health. The supplement increases vasodilation which reduces resistance against blood flow leading to lower blood pressure levels.
A study conducted on 14 healthy men showed that consuming an L-arginine supplement for two weeks significantly reduced systolic and diastolic blood pressure compared to a placebo group (1).
Another study involving 50 patients with high cholesterol showed that L-arginine supplementation reduced total cholesterol levels by 10% after six months (2).
2) Enhanced Exercise Performance
Nitric oxide plays an essential role in increasing blood flow during exercise leading to better oxygen delivery to muscles resulting in improved performance.
In one study involving eight male cyclists who consumed a single dose of beetroot juice high in nitrates had significant improvements in time-to-exhaustion and power output during cycling (3).
Another study involving 14 healthy men showed that taking an L-arginine supplement for four weeks improved exercise endurance by increasing oxygen uptake and reducing the rate of fatigue (4).
3) Reduced High Blood Pressure During Pregnancy
High blood pressure during pregnancy can lead to various complications like pre-eclampsia, which can be life-threatening for both mother and baby.
A study conducted on 40 pregnant women with high blood pressure showed that consuming a nitric oxide supplement containing L-arginine and antioxidants significantly reduced blood pressure levels compared to a placebo group (5).
4) Improved Erectile Dysfunction
Nitric oxide plays an essential role in vasodilation, including penile vessels. Erectile dysfunction is often caused by poor blood flow to the penis leading to inadequate erections.
A randomized controlled trial involving 50 patients with erectile dysfunction showed that consuming an L-arginine supplement significantly improved erectile function compared to a placebo group (6).
5) Improved Healing Processes
Nitric oxide also contributes to wound healing by improving blood flow and promoting angiogenesis (the formation of new blood vessels).
A study conducted on rats showed that topical application of nitric oxide gel significantly improved wound healing rates compared to control groups(7). Another study found similar results when using nitric oxide patches for diabetic foot ulcers(8).
The Science Behind Nitric Oxide Supplementation
Scientists have conducted numerous clinical trials on the effectiveness and safety of nitric oxide supplements. Most studies have shown significant benefits without any adverse side effects.
One meta-analysis reviewed 22 studies involving over 1200 participants concluded that supplementation improves aerobic performance in healthy individuals(9). Another review concluded that L-citrulline supplementation improves exercise tolerance in people with heart failure without adverse effects(10).
Conclusion
Nitric oxide supplementation is an effective way to improve cardiovascular health, exercise performance, reduce high blood pressure during pregnancy, treat erectile dysfunction and promote wound healing.
L-arginine and L-citrulline supplementation contribute to nitric oxide levels in the body leading to vasodilation that improves blood flow throughout the body including muscles during exercise.
Scientists have conducted numerous clinical trials on the effectiveness and safety of nitric oxide supplements leading to overwhelming positive results. However, some studies have reported negative side effects like nausea or headaches, so it’s essential to consult with a healthcare professional before taking any new supplement.